双语:11种危险基因易致老年痴呆

2014年03月14日14:47  新东方 微博   

  科学家们新发现了11种导致老年痴呆发病的危险基因。这是迄今为止全球最大规模的老年痴呆症调研项目。来自15个国家,共5万多人参与了此次抽样调研。以下是 BBC 记者James Gallagher 发回的报道:

  Alzheimer's disease is a growing burden around the world. Yet basic questions such as what causes it or how to diagnose it remain unanswered. A global team of scientists searched through the DNA of more than 50,000 people in the hunt for clues. The study, published in Nature Genetics, identified 11 new genes on top of the ten already discovered. All can increase the chances of developing the dementia.

    阿尔茨海默氏症,俗称老年痴呆症,正日益加重世界负担,但时至今日,对于此病症的基本问题,如致病原因、如何诊断等还有待探究。由全球顶尖科学家组成的一支科研队伍,提取了50,000人的不同基因序列,并通过研究确定其中的11个基因是易导致老奶痴呆症的主要诱因。

  One of the lead scientists, Professor Julie Williams from Cardiff University, said working out the genes' role in Alzheimer's could lead to treatments. "It's not, you know, 21 different theories about Alzheimer's. They are forming patterns so we can look at a few different processes and try and understand those and then produce treatments from there."

    其中一位来自卡蒂夫大学的资深科学教授称,找出这些基因对于进一步解决此病症有很大帮助:“精准定位这些基因并不是理论研究,其更具实际意义,这是迈向今后进一步确定治疗方法,更全面掌握病理等方面研究的重要一步。”

  Those patterns centre on the immune system, how the body deals with cholesterol and how cells in the brain transport material. But this is the first step. Further studies are now needed to identify precisely what is going wrong and to begin the slow process of converting the findings into treatments.

    身体如何处理胆固醇,大脑细胞如何运输信息以及其他免疫系统功能问题都是此项研究的重点。但这仅仅是第一步,今后还需要更深入的研究并定位基因本身,以及基因变异后漫长的致病过程,并逐步将这些发现应用于疾病的治疗中。

                                                                                                      (编译:马晴)

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