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研究发现食用红辣椒和花椰菜能防癌
http://www.sina.com.cn 2005/04/21 19:16  国际在线

  Broccoli and red chili peppers may help fight cancer by slowing the growth of cancerous tumor cells, U.S. researchers reported on Tuesday.

  They may be especially helpful in hard-to-treat cancers such as pancreatic and ovarian cancer, the team at the University of Pittsburgh said.

  "In our studies, we decided to look at two particular cancers -- ovarian and pancreatic -- with low survival rates, to ascertain the contribution of diet and nutrition to the development of these cancers," said Sanjay Srivastava, who led the study.

  "We discovered that red chili pepper and broccoli appear to be effective inhibitors of the cancer process."

  Speaking to a meeting of the American Association for Cancer Research in Anaheim, California, Srivastava said he and colleagues tested capsaicin, which makes peppers hot, against pancreatic cancer cells in a lab dish.

  The compound caused the cancer cells to self-destruct in a process called apoptosis, while not affecting normal pancreatic cells.

  "Our results demonstrate that capsaicin is a potent anticancer agent, induces apoptosis in cancer cells and produces no significant damage to normal pancreatic cells, indicating its potential use as a novel chemotherapeutic agent for pancreatic cancer," Srivastava said.

  His team also examined phenethyl isothiocyanate (PEITC), a constituent of cruciferous vegetables such as broccoli, on ovarian cancer cells.

  PEITC interfered with a protein called epidermal growth factor receptor, which is involved in the growth of ovarian and other cancerous tumors.

  The studies may help explain why people who eat large amounts of fruits and vegetables have a lower risk of cancer, Srivastava said.

研究发现食用红辣椒和花椰菜能防癌

  美国匹兹堡大学一个研究小组日前表示,食用辣椒和花椰菜可能对于预防癌症有好处,尤其是对一些难以治愈的癌症,如胰腺癌和卵巢癌具有帮助作用。

  据路透社4月19日报道,这项研究的负责人桑贾伊·斯里瓦斯塔瓦说:“在我们的研究过程中,我们将重点放在两种特殊的癌症——胰腺癌和卵巢癌上,患有这两种癌症的病人幸存率都很低。我们决定以此来判断饮食及营养会给这些癌症的发展带来何种影响。”他说,“我们发现红辣椒和花椰菜似乎是癌症发展的有效抑止剂”。

  斯里瓦斯塔瓦还进一步表示,他和同事在试验室发现,使辣椒具有辣味的辣椒素对胰腺癌细胞具有抑止作用。在一种被称为凋亡(Apoptosis,凋亡是细胞死亡的机制之一)的过程中,辣椒素可以使癌细胞进行自我破坏,但是却不会影响到其它正常的胰腺细胞。他说:“我们的结果证明,辣椒素是一种有效的抗癌剂,它能促使癌细胞发生凋亡,但是却不会对正常的胰腺细胞产生负面影响。这可能给我们带来一个治疗胰腺癌的新化学疗法药剂。”

  斯里瓦斯塔瓦的研究小组还检测分析了存在于花椰菜等十字花科蔬菜中的异硫氰酸苯乙酯(phenethylisothiocyanate,PEITC)对卵巢癌细胞产生的作用。研究显示,异硫氰酸苯乙酯能够对一种名为表皮生长因子受体(epidermal growth factor receptor)的蛋白质产生干扰作用,而这种蛋白和卵巢癌及其它癌瘤的发展有关。

  报道说,这项研究或许能帮助解释为什么那些食用大量蔬菜水果的人患癌症的风险要比其他人低的原因。(文/王高山)


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